Controlled trial of a short and a prolonged course with ciprofloxacin in patients undergoing transurethral prostatic surgery

Summary, in English

The efficacy of a short (Group I) and a prolonged (Group II) course with ciprofloxacin was assessed in patients undergoing transurethral prostatic resection for benign hyperplasia or cancer of the prostate and compared with that of controls without antibiotic (Group III). Both regiments significantly reduced the frequency of postoperative bacteriuria (p less than 0.01) and of severe infectious complications (p = 0.004) as compared to the controls. Both regimens were equally effective in preventing perioperative and postoperative acquisition of bacteriuria in patients without bacteriuria at surgery. In patients with bacteriuria before surgery, bacteriuria was found postoperatively in 35% in Group I and 10% in Group II (p = 0.012), but in 82% of the patients in Group III. Ciprofloxacin inhibited all but 7 of 176 bacterial strains at an MIC of less than or equal to 1 microgram/ml. Given orally ciprofloxacin is a valuable alternative antimicrobial for use in conjunction with transurethral prostatic resection. A short course is sufficient for prophylaxis, and adequate therapy is achieved with a prolonged regimen.

• Författare: Magnus Grabe; Arne Forsgren; Thomas Björk; Sverker Hellsten
• Avdelning/ar: Institutionen för kliniska vetenskaper, Malmö; Urologisk cancerforskning, Malmö; Klinisk mikrobiologi, Malmö
• Publiceringsår: 1987
• Språk: Engelska
• Sidor: 11-17
• Publikation/Tidskrift/Serie: European Journal of Clinical Microbiology and Infectious Diseases
• Volym: 6
• Issue: 1
• Länkar: http://dx.doi.org/10.1007/BF02097183
• Dokumenttyp: Artikel i tidskrift
• Förlag: Springer
• Ämne: Microbiology in the medical area; Clinical Medicine; Urology and Nephrology; Cancer and Oncology
• Status: Published
• Forskningsgrupp: Urological cancer, Malmö; Clinical Microbiology, Malmö
• ISBN/ISSN/Övrigt: ISSN: 0722-2211