5-Hydroxytryptamine stimulates the formation of inositol phosphate in astrocytes from different regions of the brain
Författare
Summary, in English
5-Hydroxytryptamine (5-HT) stimulated the turnover of phosphoinositide in primary cultures of astroglia from the cerebral cortex, striatum, hippocampus and brain stem. Ketanserin and ritanserin, selective antagonists for the central 5-HT2 receptor, inhibited the 5-HT-stimulated formation of inositol monophosphate. In contrast, there was no statistically significant accumulation of cyclic AMP after incubation with different concentrations of 5-HT in any of the cultures studied. The results indicate that astrocytes from various regions of the brain possess 5-HT2 receptors coupled to the formation of inositol phosphates.
Publiceringsår
1987
Språk
Engelska
Sidor
1377-1382
Publikation/Tidskrift/Serie
Neuropharmacology
Volym
26
Issue
9
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Pharmacology and Toxicology
Nyckelord
- brain stem
- hippocampus
- striatum
- second messenger
- astroglial primary culture
- cerebral cortex
- diacylglycerol
- inositol trisphosphate
- 5-HT2-receptor
Status
Published
Forskningsgrupp
- Clinical Chemistry, Malmö
ISBN/ISSN/Övrigt
- ISSN: 1873-7064