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Radioimmunoassay of beta-microseminoprotein, a prostatic-secreted protein present in sera of both men and women

In English

Författare

Summary, in English

We describe a simple radioimmunoassay of beta-microseminoprotein, one of the three most abundant secretory proteins of the prostate gland. The detection limit of the assay is 1 microgram/L, and its precision, expressed as the total coefficient of variation, is less than 10% for values between 10 and 150 micrograms/L. Using this assay, we found that beta-microseminoprotein immunoreactivity was present in sera from both sexes at about the same concentration. The protein detected had the same molecular size on gel chromatography as the protein isolated from seminal plasma, and dilution curves for the sera paralleled that for the pure protein. The findings suggest that beta-microseminoprotein is present in serum of healthy subjects of both sexes and that it originates in tissue other than the prostate gland. The range of the serum concentration was 0-10.6 micrograms/L (median 4.1) for 51 healthy adult women and 1.1-14.7 micrograms/L (median 6.2) for 35 healthy adult men not older than 40 years. In males with prostatic cancer the concentration in serum was highly variable and often greatly increased. The concentration of beta-microseminoprotein was correlated with that of creatinine in serum, suggesting that the protein is eliminated--at least partly--from the circulation by glomerular filtration. Little of the protein was present in the urine of women. In urine from men the concentration was high and variable, probably because of local contribution from the prostate gland to the urethral urine.

Publiceringsår

1989

Språk

Engelska

Sidor

1497-1503

Publikation/Tidskrift/Serie

Clinical Chemistry

Volym

35

Issue

7

Dokumenttyp

Artikel i tidskrift

Förlag

American Association for Clinical Chemistry

Ämne

  • Biochemistry and Molecular Biology

Nyckelord

  • fertility
  • gonadotropins
  • beta-inhibin
  • prostatic cancer
  • reference values
  • renal function
  • seminal plasma
  • urine

Status

Published

Forskningsgrupp

  • Urological cancer, Malmö
  • Clinical Chemistry, Malmö

ISBN/ISSN/Övrigt

  • ISSN: 0009-9147