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Adrenoceptors mediating contraction in the human uterine artery

In English

Författare

Summary, in English

Pharmacological characterization of adrenoceptors mediating smooth muscle contraction was performed in isolated preparations from the human uterine artery. The mixed alpha 1- and alpha 2-adrenergic agonist, noradrenaline (NA) and the selective alpha 1-agonists, phenylephrine and methoxamine, all contracted the smooth muscle preparations in a concentration-dependent manner. The responses were antagonized competitively by the selective alpha 1-antagonist, prazosin, yielding pA2 values for the three agonists (8.33-9.08) typical for an interaction with alpha 1-receptors. The alpha 2-selective receptor agonists, clonidine and BHT 920, did not exert any contractile effects in the isolated uterine arteries, and the alpha 2-adrenergic antagonist, yohimbine, counteracted the contractile effect of NA only at high concentrations. The concentration-response curve for NA was unaffected by the alpha 2-selective antagonists, rauwolscine and idazoxan. The results suggest that the postjunctional contractile receptors in the human uterine artery primarily are of the alpha 1 type, and give no evidence for any substantial involvement of alpha 2-receptors in this important tributary vessel of the human female reproductive tract.

Avdelning/ar

Publiceringsår

1990

Språk

Engelska

Sidor

19-24

Publikation/Tidskrift/Serie

Human Reproduction

Volym

5

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

Oxford University Press

Ämne

  • Obstetrics, Gynecology and Reproductive Medicine
  • Pharmacology and Toxicology

Nyckelord

  • adrenoceptors/noradrenaline/uterine artery/vascular/smooth muscle

Status

Published

Forskningsgrupp

  • Urogynaecology and Reproductive Pharmacology
  • Drug Target Discovery

ISBN/ISSN/Övrigt

  • ISSN: 0268-1161