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Flow cytometric DNA index and S-phase fraction in breast cancer in relation to other prognostic variables and to clinical outcome

In English

Författare

Summary, in English

One frequently used classification of flow cytometric DNA ploidy status (diploid versus nondiploid) was compared with a division into seven ploidy classes based on DNA index (DI) and number of cell populations (hypodiploid, diploid, near-hyperdiploid, hyperdiploid, tetraploid, hypertetraploid, and multiploid). The latter ploidy classification showed a better correlation with prognosis and other prognostic factors (i.e., lymph node involvement, estrogen and progesterone receptor status, and S-phase fraction). The improvement in correlation was mainly due to the identification of near-hyperdiploid cases (DI 1.00-1.14) which could be combined with the diploid cases to form a group with favourable prognosis. In contrast to cases with a small increase in DNA content (near-hyperdiploid), those with a small decrease of DNA content (hypodiploid) manifested a more aggressive disease. In multivariate analysis, S-phase fraction (SPF) was a more important prognostic factor than both the improved or the conventional ploidy classification.

Publiceringsår

1992

Språk

Engelska

Sidor

157-165

Publikation/Tidskrift/Serie

Acta Oncologica

Volym

31

Issue

2

Dokumenttyp

Artikel i tidskrift

Förlag

Taylor & Francis

Ämne

  • Cancer and Oncology

Nyckelord

  • Breast cancer
  • flow cytometry
  • DNA-index
  • ploidy
  • S-phase
  • interphase
  • proliferation
  • prognosis

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1651-226X