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Neocortical grafts placed in the infarcted brain of adult rats: few or no efferent fibers grow from transplant to host

In English

Författare

  • Martin Grabowski
  • Barbro Johansson
  • Patrik Brundin

Summary, in English

The present study examines the capacity of fetal neocortical grafts placed in a brain infarct to exchange axonal projections with the host brain. Five to 7 days after a middle cerebral artery occlusion in adult spontaneously hypertensive rats, dissociated neocortical primordium from fetuses of gestational age 15-16 days was implanted into the infarcted area. Four to 11 months later, the neural tracers Phaseolus vulgaris-leucoagglutinin and Fluoro-Gold were injected in the grafts and host neocortex. An extensive axonal network was present in the transplants but only one of eight rats with appropriate placed injections displayed efferent connections from transplant to host. The sparse axonal outgrowth indicates major limitations for fetal rat cortical grafts to form connections with host neural circuitries after an ischemic insult.

Publiceringsår

1995

Språk

Engelska

Sidor

273-276

Publikation/Tidskrift/Serie

Experimental Neurology

Volym

134

Issue

2

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Neurology

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 0014-4886