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Inflammatory reaction dependence on implant localization in rat soft tissue models

In English

Författare

Summary, in English

This study compares two different implantation models in soft tissue in rat abdominal wall with regard to inflammatory reactions. Titanium rods and discs, penetrating or not penetrating the peritoneal wall respectively, were implanted. After 3, 10 or 30 days the distribution of monocytes/macrophages and cytokines (interleukin-1 and transforming growth factor-beta) in the tissue adjacent to the implants was investigated under immunohistochemistry. The macrophage-specific antibody, ED1, was used for the identification of newly recruited macrophages and the ED2 antibody was used for the mature tissue macrophages. After 10 days the non-penetrating implants had a larger number of cells close to the implant than the penetrating implants. The opposite was seen after 30 days implantation, with a larger number of cells around the penetrating implants. At all time intervals the penetrating implants had a thicker reactive capsule. The cytokines interleukin-1beta and transforming growth factor-beta could be detected in the reactive tissue adjacent to both types of implants, without obvious differences for the two implant situations. The biocompatibility of a material appears to be influenced by the localization of the implant. In addition, it seems to be of importance to extend the follow-up periods further, as we cannot assume that steady state is reached at 30 days implantation.

Publiceringsår

1997

Språk

Engelska

Sidor

979-987

Publikation/Tidskrift/Serie

Biomaterials

Volym

18

Issue

14

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Bioengineering Equipment

Nyckelord

  • Titanium
  • peritoneal implants
  • macrophages
  • immunohistochemistry
  • soft tissue

Status

Published

Forskningsgrupp

  • Neural Interfaces

ISBN/ISSN/Övrigt

  • ISSN: 1878-5905