Minor components with smooth muscle relaxing properties from scented myrrh (Commiphora guidotti)
Författare
Summary, in English
All sesquiterpenes present in a sample of scented myrrh were isolated and characterised. Seven compounds, with cadinane, guaiane, oplopane, and eudesmane skeletons, were obtained, of which two are new and two are reported from a natural source for the first time. The major component, T-cadinol, has previously been shown to possess smooth muscle-relaxing properties, and the major purpose of the investigation was to compare the effects of the minor and more polar sesquiterpenes with that of T-cadinol in the rat aorta. Like T-cadinol, the minor sesquiterpenes are more efficient in reducing K(+)-induced contractions than those induced by the alpha-adrenoceptor agonist phenylephrine, however, they were all less potent than T-cadinol.
Avdelning/ar
Publiceringsår
1997
Språk
Engelska
Sidor
251-254
Publikation/Tidskrift/Serie
Planta Medica
Volym
63
Issue
3
Dokumenttyp
Artikel i tidskrift
Förlag
Georg Thieme Verlag
Ämne
- Medicinal Chemistry
- Dermatology and Venereal Diseases
- Pharmacology and Toxicology
Nyckelord
- Scented myrrh
- Commiphora guidotti
- Burseraceae
- sesquiterpenes
- T-cadinol
- smooth muscle relaxant
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0032-0943