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Anti-inflammatory properties of titanium in the joint environment. An experimental study in rats

In English

Författare

Summary, in English

Little is known about the tissue reactions to various implant materials which coincide with an inflammatory reaction. We used the avridine arthritis rat model to evaluate the tissue response in the synovial, interstitial and subcutaneous tissues after implant insertion. Quantitative immunohistochemistry showed that normal joint synovial tissue is dominated by ED2-positive resident macrophages. Polyethylene implants induced a much stronger foreign-body reaction than titanium implants, as measured by the number of interfacial ED1-positive macrophages. The tissue response to titanium and polyethylene was also vastly different in arthritic synovial tissue compared with control tissue. It is likely that these biomaterials interact differently with inflammatory cells or intermediary compounds. It may be that arthritic synovial tissue produces reactive oxygen intermediates (free radicals) with which titanium has a unique anti-inflammatory interaction in vitro.

Publiceringsår

1998

Språk

Engelska

Sidor

888-893

Publikation/Tidskrift/Serie

Journal of Bone and Joint Surgery: British Volume

Volym

80-B

Issue

5

Dokumenttyp

Artikel i tidskrift

Förlag

British Editorial Society of Bone & Joint Surgery

Ämne

  • Neurosciences
  • Medical Biotechnology

Status

Published

Forskningsgrupp

  • Neural Interfaces

ISBN/ISSN/Övrigt

  • ISSN: 2044-5377