Five homologous repeats of the protein G-related protein MIG cooperate in binding to goat immunoglobulin G

Summary, in English

Protein MIG, from Streptococcus dysgalactiae, binds alpha2-macroglobulin and immunoglobulin G (IgG). MIG-derived fusion proteins with one to five IgG-binding repeats differed up to 72,000- fold in avidity for goat IgG, indicating a considerable cooperativity of the repeats. Significant sequence variation in the IgG-binding repeats was recognized. Protein MIG interacted with goat IgG1 via both the Fc and Fab parts.

• Författare: J Vasi; J Svensson; Inga-Maria Frick; H P Muller
• Avdelning/ar: Infektionsmedicin
• Publiceringsår: 1999
• Språk: Engelska
• Sidor: 413-416
• Publikation/Tidskrift/Serie: Infection and Immunity
• Volym: 67
• Issue: 1
• Länkar: http://iai.highwire.org/cgi/content/full/67/1/413
• Dokumenttyp: Artikel i tidskrift
• Förlag: American Society for Microbiology
• Ämne: Infectious Medicine
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1098-5522