PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.

Summary, in English

Platelet-derived growth factors (PDGFs) are important in many types of mesenchymal cell. Here we identify a new PDGF, PDGF-C, which binds to and activates the PDGF alpha-receptor. PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. In situ hybridization analysis in the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion. Analysis of kidneys lacking the PDGF alpha-receptor shows selective loss of mesenchymal cells adjacent to sites of expression of PDGF-C mRNA; this is not found in kidneys from animals lacking PDGF-A or both PDGF-A and PDGF-B, indicating that PDGF-C may have a unique function.

• Författare: X. Li; A. Pontén; K. Aase; L. Karlsson; A. Abramsson; M. Uutela; G. Bäckström; M. Hellström; Hans Ehrencrona; H. Li; P. Soriano; C. Betsholtz; C. H. Heldin; K. Alitalo; A. Ostman; U. Eriksson
• Publiceringsår: 2000
• Språk: Engelska
• Sidor: 302-309
• Publikation/Tidskrift/Serie: Nature Cell Biology
• Volym: 2
• Issue: 5
• Länkar: http://dx.doi.org/10.1038/35010579; http://www.ncbi.nlm.nih.gov/pubmed/10806482; http://dx.doi.org/10.1038/35010579
• Dokumenttyp: Artikel i tidskrift
• Förlag: Nature Publishing Group
• Ämne: Cell and Molecular Biology
• Nyckelord: Platelet-Derived Growth Factor; Myocardium; Molecular Sequence Data; Mice; Mesoderm; Lymphokines; Ligands; Kidney; Insects; In Situ Hybridization; Humans; Developmental; Gene Expression Regulation; Gene Expression; Epithelial Cells; Endopeptidases; Animals; COS Cells; Protein Structure; Tertiary; RNA; Messenger; Rabbits; Receptor; Platelet-Derived Growth Factor alpha; Sequence Homology; Amino Acid; Transgenes
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1465-7392