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PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor

  • X Li
  • Annica Pontén
  • K Aase
  • L Karlsson
  • A Abramsson
  • M Uutela
  • G Backstrom
  • M Hellstrom
  • H Bostrom
  • H Li
  • P Soriano
  • C Betsholtz
  • C H Heldin
  • K Alitalo
  • A Ostman
  • U Eriksson
Publiceringsår: 2000
Språk: Engelska
Sidor: 302-309
Publikation/Tidskrift/Serie: Nature cell biology
Volym: 2
Nummer: 5
Dokumenttyp: Artikel
Förlag: Nature Publishing Group


Platelet-derived growth factors (PDGFs) are important in many types of mesenchymal cell. Here we identify a new PDGF, PDGF-C, which binds to and activates the PDGF alpha-receptor. PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. In situ hybridization analysis in the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion. Analysis of kidneys lacking the PDGF alpha-receptor shows selective loss of mesenchymal cells adjacent to sites of expression of PDGF-C mRNA; this is not found in kidneys from animals lacking PDGF-A or both PDGF-A and PDGF-B, indicating that PDGF-C may have a unique function.



  • Medicine and Health Sciences


  • ISSN: 1465-7392

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