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Neurocan is dispensable for brain development

In English

Författare

  • Xiao-Hong Zhou
  • Cord Brakebusch
  • Henry Matthies
  • Toshitaka Oohashi
  • Emilio Hirsch
  • Markus Moser
  • Manfred Krug
  • Constanze I. Seidenbecher
  • Tobias M. Boeckers
  • Uwe Rauch
  • Reinhard Buettner
  • Eckart D. Gundelfinger
  • Reinhard Fässler
Visa allt

Summary, in English

Neurocan is a component of the extracellular matrix in brain. Due to its inhibition of neuronal adhesion and outgrowth in vitro and its expression pattern in vivo it was suggested to play an important role in axon guidance and neurite growth. To study the role of neurocan in brain development we generated neurocan-deficient mice by targeted disruption of the neurocan gene. These mice are viable and fertile and have no obvious deficits in reproduction and general performance. Brain anatomy, morphology, and ultrastructure are similar to those of wild-type mice. Perineuronal nets surrounding neurons appear largely normal. Mild deficits in synaptic plasticity may exist, as maintenance of late-phase hippocampal long-term potentiation is reduced. These data indicate that neurocan has either a redundant or a more subtle function in the development of the brain.

Publiceringsår

2001

Språk

Engelska

Sidor

5970-5978

Publikation/Tidskrift/Serie

Molecular and Cellular Biology

Volym

21

Issue

17

Dokumenttyp

Artikel i tidskrift

Förlag

American Society for Microbiology

Ämne

  • Cell and Molecular Biology

Status

Published

Forskningsgrupp

  • Vessel Wall Biology

ISBN/ISSN/Övrigt

  • ISSN: 0270-7306