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Markedly reduced chronic nociceptive response in mice lacking the PAC1 receptor

Författare:
Publiceringsår: 2001
Språk: Engelska
Sidor: 2215-2219
Publikation/Tidskrift/Serie: Neuroreport
Volym: 12
Nummer: 10
Dokumenttyp: Artikel
Förlag: Lippincott Williams & Wilkins

Sammanfattning

The neuropeptide pituitary adenylate cyclase activating polypeptide (PACAP) has been proposed to have a role in nociception. Here we have used the formalin test, thermal laser stimulation and mechanical von Frey stimulation to investigate possible alteration of PAC1-/- mice nociceptive behaviour. Our finding, that PAC1-/- mice have a substantial, 75% decrease in nociceptive response during the late phase, provides clear evidence that the specific PACAP-receptor PAC1 is involved in the mediation of nociceptive responses during chronic conditions such as inflammation. PAC1-/- mice had small or no changes in the response to mechanical and thermal laser stimulation. This suggests a limited, if any, involvement of PAC1 in nociception after short-lasting stimuli. Injury-induced changes in DRG neuropeptide expression were more pronounced in PAC1-/- mice, implying neuroregulatory functions of PAC1.

Disputation

Nyckelord

  • Medicine and Health Sciences
  • Dorsal root ganglion
  • Formalin test
  • Inflammation
  • Mechanical von Frey
  • Neuropeptides
  • PACAP
  • Pain measurements
  • Sciatic nerve injury
  • Sensory thresholds
  • Thermal laser

Övriga

Published
Yes
  • ISSN: 0959-4965

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