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A novel diffusible substance can overcome the apparent AbrB repression of the Bacillus subtilis fatR promoter

Publiceringsår: 2001
Språk: Engelska
Sidor: 197-202
Publikation/Tidskrift/Serie: FEMS Microbiology Letters
Volym: 199
Nummer: 2
Dokumenttyp: Artikel
Förlag: Elsevier Science Bv

Sammanfattning

In this work we present evidence for a novel diffusible extracellular factor that modulates gene expression in Bacillus subtilis. The factor was found when studying the regulation of the fatR-cyp102A3 operon. In a Spo0A(-) mutant expression of the fatR-cyp102A3 operon was almost abolished. The fatR-cyp102A3 expression defect of a Spo0A(-) mutant could be overcome either by a mutation in the abrB gene or by a diffusible substance excreted by wild-type, abrB mutant and abrB-spo0A double mutant strains.

Disputation

Nyckelord

  • Biology and Life Sciences
  • Cytochrome P450
  • AbrB
  • FatR
  • Bacillus subtilis

Övriga

Published
Yes
  • ISSN: 0378-1097

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