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Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma)

In English

Författare

Summary, in English

In 44 consecutive patients with systemic sclerosis (SSc), plasma concentrations of von Willebrand factor (vWf) were higher than those of the vWf propeptide, but the propeptide showed less variability within patient subgroups. Higher values of the propeptide were observed in patients with early pulmonary involvement. A closer correlation of the propeptide than of vWf to biochemical markers of activity was also evident. Our results suggest that the propeptide, despite a shorter circulating half-time and lower plasma concentrations than vWf, is more useful in the assessment of disease activity in SSc.

Publiceringsår

2001

Språk

Engelska

Sidor

178-182

Publikation/Tidskrift/Serie

Arthritis Research & Therapy

Volym

3

Issue

3

Dokumenttyp

Artikel i tidskrift

Förlag

BioMed Central (BMC)

Ämne

  • Rheumatology and Autoimmunity

Nyckelord

  • systemic sclerosis
  • von Willebrand factor
  • von Willebrand factor propeptide

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1465-9913