A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs.
Författare
Summary, in English
Fatty acids, which are essential nutritional components, are also involved in cardiovascular and metabolic diseases. Here we report a human cell surface receptor that we name free fatty acid receptor (FFAR), because it is specifically activated by medium to long-chain free fatty acids. The receptor belongs to the class of seven-transmembrane, G-protein coupled receptors (GPCRs) and also mediates responses to antidiabetic drugs of the thiazolidinedione type. It is expressed in skeletal muscle, heart, liver, and pancreatic β-cells. Stimulation of FFAR increases the intracellular calcium concentration in cells expressing the receptor in a native (pancreatic β-cell line) or in a recombinant form. In view of the nature of the activating substances, their physiological role in the body, and the tissue distribution of FFAR we suggest the term “nutrient sensing receptor” for receptors acting at the interface between dietary components and signalling molecules.
Avdelning/ar
- Slemhinnans immunologi
- Institutionen för experimentell medicinsk vetenskap
- Drug Target Discovery
- Immunology
Publiceringsår
2003
Språk
Engelska
Sidor
406-410
Publikation/Tidskrift/Serie
Biochemical and Biophysical Research Communications
Volym
301
Issue
2
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Biological Sciences
Nyckelord
- Reverse pharmacology
- Arteriosclerosis
- Obesity
- Diabetes
- Thiazolidinediones
- Fatty acid
- GPR40
- Receptor
- Cell surface
- Preclinical
- Drug evaluation
Aktiv
Published
Forskningsgrupp
- Mucosal Immunology
- Drug Target Discovery
- Immunology
ISBN/ISSN/Övrigt
- ISSN: 1090-2104