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Additional transplantation of ex vivo generated megakaryocytic cells after high-dose chemotherapy

  • Stefan Scheding
  • Markus Bergmannn
  • Gisa Rathke
  • Wichard Vogel
  • Wolfram Brugger
  • Lothar Kanz
Publiceringsår: 2004
Språk: Engelska
Sidor: 630-631
Publikation/Tidskrift/Serie: Haematologica
Volym: 89
Nummer: 5
Dokumenttyp: Artikel
Förlag: Ferrata Storti Foundation


The additional transplantation of ex vivo generated hematopoietic (post)-progenitor cells represents a possible approach to ameliorate high-dose chemotherapy induced cytopenia. We investigated the feasibility of the large-scale expansion and transplantation of autologous megakaryocytic cells in four patients with advanced solid tumors. Up to 1,460x10(6) ex vivo generated cells were administered without adverse effects but no clear cut effect on platelet recovery was observed.



  • Medicine and Health Sciences


  • ISSN: 1592-8721

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