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Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors

Författare:
  • Xuri Li
  • Marc Tjwa
  • Lieve Moons
  • Pierre Fons
  • Agnes Noel
  • Annelii Ny
  • Jian Min Zhou
  • Johan Lennartsson
  • Hong Li
  • Aernout Luttun
  • Annica Pontén
  • Laetitia Devy
  • Ann Bouche
  • Hideyasu Oh
  • Ann Manderveld
  • Silvia Blacher
  • Davi Communi
Publiceringsår: 2005
Språk: Engelska
Sidor: 118-127
Publikation/Tidskrift/Serie: The Journal of clinical investigation
Volym: 115
Nummer: 1
Dokumenttyp: Artikel
Förlag: The American Society for Clinical Investigation

Sammanfattning

The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore, PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and stimulated their growth during vessel sprouting. Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases.

Disputation

Nyckelord

  • Medicine and Health Sciences

Övriga

Published
Yes
  • ISSN: 0021-9738

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