Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors
Publikation/Tidskrift/Serie: The Journal of clinical investigation
Förlag: The American Society for Clinical Investigation
The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore, PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and stimulated their growth during vessel sprouting. Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases.
- Cell and Molecular Biology
- ISSN: 0021-9738