Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors

In English

Författare

  • Xuri Li
  • Marc Tjwa
  • Lieve Moons
  • Pierre Fons
  • Agnes Noel
  • Annelii Ny
  • Jian Min Zhou
  • Johan Lennartsson
  • Hong Li
  • Aernout Luttun
  • Annica Pontén
  • Laetitia Devy
  • Ann Bouche
  • Hideyasu Oh
  • Ann Manderveld
  • Silvia Blacher
  • Davi Communi
Visa allt

Summary, in English

The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore, PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and stimulated their growth during vessel sprouting. Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases.

Publiceringsår

2005

Språk

Engelska

Sidor

118-127

Publikation/Tidskrift/Serie

Journal of Clinical Investigation

Volym

115

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

The American Society for Clinical Investigation

Ämne

  • Cell and Molecular Biology

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 0021-9738