Du är här

Intestinal bacteria and permeability during experimental acute pancreatitis in rats

Författare:
Publiceringsår: 2006
Språk: Engelska
Sidor: 276-284
Publikation/Tidskrift/Serie: Annals of Gastroenterology
Volym: 19
Nummer: 3
Dokumenttyp: Artikel
Förlag: Hellenic Society of Gastroenterology

Sammanfattning

Background: An increase in intestinal permeability and subsequent bacterial translocation has been demonstrated in
critical illness. Cellulose derivatives have in the past been shown to reduce gut leakage following liver resection.

Aims: The aim of the present study was to evaluate changes
in microbial counts in experimental acute pancreatitis and
the effect of pre-treatment with cellulose derivatives and
N-acetyl cysteine.

Subjects: 92 male Sprague Dawley rats.
Methods: Acute pancreatitis was induced by intraductal taurodeoxycholic acid infusion. Animals received oral pretreatment and were randomized to either sham operation
or the pancreatitis groups, with or without pre-treatment
with cellulose derivatives, the antioxidant or their combinations. Intestinal bacterial populations and permeability were evaluated using bacterial counts and Ussing chamber, respectively.

Results: The number of E. coli increased in the luminal content and ileal and colonic mucosa, but levels were restored to almost those seen in controls in all pre-treatment groups except for N-acetyl cysteine. When intestinal permeability was measured, none of the treatment groups showed significant differences compared to challenge, except for Nacetyl cysteine, which significantly increased permeability.

Conclusion: Pre-treatment with cellulose derivatives was
more efficient against disturbances in intestinal permeability and microbial populations than the antioxidant Nacetyl cysteine.

Disputation

Nyckelord

  • Medicine and Health Sciences
  • dietary fibres
  • acute pancreatitis
  • bacterial counts
  • intestinal permeability

Övriga

Published
Yes
  • ISSN: 1108-7471

Box 117, 221 00 LUND
Telefon 046-222 00 00 (växel)
Telefax 046-222 47 20
lu [at] lu [dot] se

 

Fakturaadress: Box 188, 221 00 LUND
Organisationsnummer: 202100-3211
Om webbplatsen