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Mer samstämmiga laboratorieresultat efter övergången till INR. Skillnaderna mellan sjukhus- och primärvårdslaboratorier utjämnade

Less variation in laboratory results after the introduction of INR.

In English

Författare

  • Andreas Hillarp
  • Nils Egberg
  • Inger Fagerberg
  • Tomas L Lindahl
  • Gunnar Nordin
  • Lennart Stigendal

Summary, in English

In 1999 a new and simplified procedure for calibration of the Owren prothrombin time (Owren PT) assay was introduced in Sweden by the national external quality assessment scheme (Equalis). The new protocol allowed local calibration by means of lyophilised national plasma calibrators and expression of results as an international normalised ratio (INR). A two-year follow-up involving analysis of data from all laboratories that have returned results to Equalis is reported. There was a significant reduction in both between-laboratory and within-laboratory variation after the introduction of the new calibration procedure. For the larger hospital laboratories analysing external controls with INR>2, the mean coefficient of variation (CV) was reduced from 9.1% to 5.6% (P<0.0001). The corresponding results from smaller laboratories in the primary

health care units showed a similar decrease in CV from 8.8% to 6.3% (P<0.0001). This study shows that the Owren PT assay is well suited for INR calibration employing calibrant plasmas.

Publiceringsår

2002

Språk

Svenska

Sidor

70-5073

Publikation/Tidskrift/Serie

Läkartidningen

Volym

99

Issue

50

Dokumenttyp

Artikel i tidskrift

Förlag

Swedish Medical Association

Ämne

  • Medicinal Chemistry

Nyckelord

  • Anticoagulants: blood
  • Anticoagulants: pharmacokinetics
  • Health Care
  • Sweden
  • Hospital: standards
  • Primary Health Care
  • Prothrombin Time
  • Quality Assurance
  • Anticoagulants: administration & dosage
  • Calibration: standards
  • Comparative Study
  • Confidence Intervals
  • English Abstract
  • Follow-Up Studies
  • Human
  • International Normalized Ratio: standards
  • Laboratories: standards
  • Laboratories

Status

Published

Forskningsgrupp

  • Clinical Chemistry, Malmö

ISBN/ISSN/Övrigt

  • ISSN: 0023-7205