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Infiltration of Mast Cells in Rat Colon Is a Consequence of Ischemia/Reperfusion.

In English

Författare

Summary, in English

Intestinal ischemia as well as mastocytosis occur in patients with inflammatory bowel disease and irritable bowel syndrome. Our aim was to clarify how ischemia with reperfusion (I/R) affects the structure, enteric neurons, and immune cells in the colon. Rats were subjected to colon ischemia for 1 h and reperfused for 1 day up to 20 weeks; sham-operated rats were used as controls. No structural remodeling of the intestinal segment was detected after I/R. The number and distribution of eosinophils were not affected by I/R. Local areas containing numerous mast cells were detected in the muscle layers, the serosa, and in and around the myenteric ganglia 4-20 weeks post ischemia. It was notable that myenteric ganglionic formations within mast-cell-rich areas virtually lacked neurons. Mast cells were rarely found in controls. In conclusion, I/R of the colon attracts mast cells, and death of myenteric neurons occurs in such locations.

Avdelning/ar

  • Neurogastroenterology

Publiceringsår

2008

Språk

Engelska

Sidor

3158-3169

Publikation/Tidskrift/Serie

Digestive Diseases and Sciences

Volym

53

Dokumenttyp

Artikel i tidskrift

Förlag

Springer

Ämne

  • Gastroenterology and Hepatology

Status

Published

Forskningsgrupp

  • Neurogastroenterology

ISBN/ISSN/Övrigt

  • ISSN: 1573-2568