A multisubstrate deoxyribonucleoside kinase from plants.
Författare
Summary, in English
Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.
Avdelning/ar
Publiceringsår
2008
Språk
Engelska
Sidor
489-490
Publikation/Tidskrift/Serie
Nucleic acids symposium series
Issue
52
Dokumenttyp
Artikel i tidskrift
Förlag
Oxford University Press
Ämne
- Biological Sciences
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0261-3166