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A multisubstrate deoxyribonucleoside kinase from plants.

Författare:
  • Anders Ranegaard Clausen
  • Lenart Girandon
  • Wolfgang Knecht
  • Sabeen Survery
  • Erik Andreasson
  • Birgitte Munch-Petersen
  • Jure Piskur (Professor)
Publiceringsår: 2008
Språk: Engelska
Sidor: 489-490
Publikation/Tidskrift/Serie: Nucleic acids symposium series
Nummer: 52
Dokumenttyp: Artikel
Förlag: Oxford University Press

Sammanfattning

Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.

Disputation

Nyckelord

  • Biology and Life Sciences

Övriga

Published
Yes
  • ISSN: 1746-8272

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