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Homocystein--markör för kärlsjukdom hos aldre med psykisk sjukdom.

In English

Författare

  • Björn Hultberg
  • Anna-Karin Nilsson
  • Lars Gustafson

Summary, in English

Many studies have reported higher total plasma homocysteine (tHcy) in elderly patients with mental illness than in control subjects. There are many different determinants of plasma tHcy concentration, including age, cobalamin/folate status, renal function and the presence of vascular disease. The presence of vascular disease may contribute to cognitive impairment. We have investigated elderly patients with regard to plasma tHcy and the presence of vascular disease. Clarification of the role of vascular risk factors in mental illness is important because most are modifiable, in contrast to other risk factors such as age and genetics. The main findings in our studies imply that elevated plasma tHcy concentration in elderly patients with mental illness is mainly associated with the presence of vascular disease and is not related to the specific psychogeriatric diagnosis. Furthermore, it seems possible that the control of conventional vascular risk factors could be guided by the level of plasma tHcy, serum cystatin C, and serum N-terminal pro-brain natriuretic peptide. Patients with an elevation of any of these parameters could be selected for a lower target level of vascular risk factors such as blood pressure cholesterol etc. than conventional target levels.

Publiceringsår

2008

Språk

Svenska

Sidor

2576-2578

Publikation/Tidskrift/Serie

Läkartidningen

Volym

105

Issue

38

Dokumenttyp

Artikel i tidskrift

Förlag

Swedish Medical Association

Ämne

  • Medicinal Chemistry
  • Pharmacology and Toxicology

Nyckelord

  • Cognition Disorders: blood
  • Cognition Disorders: complications
  • Homocysteine: blood
  • Mental Disorders: blood
  • Vascular Diseases: etiology
  • Mental Disorders: complications
  • Vascular Diseases: blood
  • Biological Markers: blood
  • Alzheimer Disease: blood
  • Alzheimer Disease: complications

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 0023-7205