CK5/6 in effusions: no difference between mesothelioma and pulmonary and nonpulmonary adenocarcinoma.
Författare
Summary, in English
OBJECTIVE: To test the performance of CK5/6 for the differentiation between mesothelioma, adenocarcinoma and benign mesothelia/proliferations in effusion cytology. STUDY DESIGN: CKS/6 immunocytochemistry was applied to ethanol-fixed cytospin preparations from 74 benign and malignant effusions. RESULTS: Reactivity was seen in 7 of 8 mesotheliomas and in 9 of 11 benign mesothelial proliferations but also in 11 of l7 pulmonary adenocarcinomas and in 12 of 31 adenocarcinomas of nonpulmonary origin. Reactivity was also found in 3 of 5 non-small cell lung carcinomas and 1 of 1 squamous carcinoma. CONCLUSION: CK5/6 reactivity was found in a considerable proportion of metastatic adenocarcinomas of pulmonary and nonpulmonary origin. The high reactivity rate in pulmonary adenocarcinomas disagrees with the results obtained with histologic sections from solid tumor tissue, and CK5/6 seems to be of very limited value as an additional marker in effusion cytology.
Avdelning/ar
Publiceringsår
2008
Språk
Engelska
Sidor
579-583
Publikation/Tidskrift/Serie
Acta Cytologica
Volym
52
Issue
5
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Karger
Ämne
- Cell and Molecular Biology
- Cancer and Oncology
Status
Published
Forskningsgrupp
- Pathology, Malmö
ISBN/ISSN/Övrigt
- ISSN: 0001-5547