Saccharomyces kluyveri as a model organism to study pyrimidine degradation.

Summary, in English

Abstract The yeast Saccharomyces kluyveri (Lachancea kluyveri), a far relative of Saccharomyces cerevisiae, is not a widely studied organism in the laboratory. However, significant contributions to the understanding of nucleic acid precursors degradation in eukaryotes have been made using this model organism. Here we review eukaryotic pyrimidine degradation with emphasis on the contributions made with S. kluyveri and how this increases our understanding of human disease. Additionally, we discuss the possibilities and limitations of this nonconventional yeast as a laboratory organism.

• Författare: Halfdan Beck; Doreen Dobritzsch; Jure Piskur
• Avdelning/ar: Biologiska institutionen; Molekylär cellbiologi
• Publiceringsår: 2008
• Språk: Engelska
• Sidor: 1209-1213
• Publikation/Tidskrift/Serie: FEMS Yeast Research
• Volym: 8
• Issue: 8
• Länkar: http://dx.doi.org/10.1111/j.1567-1364.2008.00442.x
• Dokumenttyp: Artikel i tidskrift
• Förlag: Oxford University Press
• Ämne: Biological Sciences
• Nyckelord: cancer; pyrimidine; nucleic acid precursors; structure–function relationship; nonconventional yeast
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1567-1364