Intrinsic laryngeal muscles are spared from degeneration in the dy(3k)/dy(3k) mouse model of congenital muscular dystrophy type 1A.

Summary, in English

Deficiency of laminin alpha2 chain leads to a severe form of congenital muscular dystrophy (MDC1A). Here, we analyzed whether the intrinsic laryngeal muscles (ILM) are spared in the dy(3K)/dy(3K) mouse model of complete laminin alpha2 chain absence. No muscle degeneration was evident; expression of various laminin chains was similar to that of limb muscles, and sustained integrin alpha7B expression was noted in laminin alpha2 chain-deficient ILM. We conclude that ILM are spared in MDC1A. Muscle Nerve 39: 91-94, 2009.

• Författare: Mattias Häger; Madeleine Durbeej-Hjalt
• Avdelning/ar: Muskelbiologi
• Publiceringsår: 2009
• Språk: Engelska
• Sidor: 91-94
• Publikation/Tidskrift/Serie: Muscle and Nerve
• Volym: 39
• Issue: 1
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/19086066?dopt=Abstract; http://dx.doi.org/10.1002/mus.21209
• Dokumenttyp: Artikel i tidskrift
• Förlag: John Wiley & Sons Inc.
• Ämne: Cell and Molecular Biology
• Status: Published
• Forskningsgrupp: Muscle Biology
• ISBN/ISSN/Övrigt: ISSN: 0148-639X