Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Species-specificity of Neisseria gonorrhoeae infection: Do human complement regulators contribute?

In English

Författare

  • Jutamas Ngampasutadol
  • Connie Tran
  • Sunita Gulati
  • Anna Blom
  • Ann E. Jerse
  • Sanjay Ram
  • Peter A. Rice

Summary, in English

Neisseria gonorrhoeae is the causative agent of gonorrhea, a disease restricted to humans. Complement forms a key arm of the innate immune system that combats gonococcal infections. N. gonorrhoeae uses its outer membrane porin (Por) molecules to bind complement clown-regulatory proteins, C4b-binding protein (C4BP) and factor H (M), to evade killing by human complement. In addition, sialylation of gonococcal lipooligosaccharide (LOS) also enables N. gonorrhoeae to bind fH. Strains of N. gonorrhoeae that resist killing by human serum complement are killed by serum from rodent, lagomorph and primate species, which cannot be readily infected experimentally with this organism and whose C4BP and/or fH molecules do not bind to N. gonorrhoeae. Serum resistance of gonococci is restored in these sera by human C4BP and/or fH Direct binding specificity of human and chimpanzee C4BP and human fH to gonococci may explain, in part, species-specific restriction of natural gonococcal infection and address why Por1B, but not Por1A containing gonococcal strains, have been successful in experimental chimpanzee infection. Our findings may help to improve animal models for gonorrhea while also having implications in the choice of complement sources to evaluate neisserial vaccine candidates. (C) 2008 Elsevier Ltd. All rights reserved.

Publiceringsår

2008

Språk

Engelska

Sidor

62-66

Publikation/Tidskrift/Serie

Vaccine

Volym

26

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Other Basic Medicine

Nyckelord

  • and factor H
  • C4b-binding protein
  • Species-specific infection
  • Gonorrhea
  • Complement

Status

Published

Forskningsgrupp

  • Protein Chemistry, Malmö

ISBN/ISSN/Övrigt

  • ISSN: 1873-2518