Prospective Study of Chemotherapy in Combination with Cytokine-induced Killer Cells in Patients Suffering from Advanced Non-small Cell Lung Cancer
Författare
Summary, in English
The present study evaluated the clinical efficacy of chemotherapy in combination with cytokine-induced killer (CIK) biotherapy compared to the chemotherapy alone. Fifty-nine advanced non-small cell lung cancer (NSCLC) patients were randomly divided into two groups, group A (chemotherapy, alone, including docetaxel 75 mg/m(2), day 1; cisplatin, 25 mg/m(2), days 1-4, tri-weekly) and group B (chemotherapy plus CIK cell transfusion). Autologous ClK cells were induced from the patients' peripheral mononuclear cells in vitro and separated by cytometry and then transfused back the patients. The host cellular immune function, clinical curative effects and quality of life (QOL) were examined and were compared between the two groups. The host immune function was enhanced and QOL was improved in the patients treated by chemotherapy, plus CIK biotherapy compared to the patients treated by chemotherapy alone. The overall response rate (ORR) was 43.3 % and 44.8% in groups A and B, respectively. The disease control rate (DCR) was higher in group B than in group A (89.7% vs. 65.5%, p=0.030). The time to progression was 4.67 months (95% CI 3.98-6.02 months) in group A and 6.65 months (95% CI 4.70-7.30 months) in group B and the median survival time was 11.0 months (95% CI 7.88-14.1 months) in group A and 15.0 months (95% CI 11.04-18.96 months) in group B. Compared to patients in group A, the patients in group B had significantly longer progression-free survival (p=0.042) and overall survival (p=0.029). No severe side-effects occurred in the ClK cell transfusion patients. It was concluded that chemotherapy plus CIK cells has potential benefits compared to chemotherapy alone in patients suffering from advanced NSCLC and autologous CIK cell transfusion has no obvious side-effects.
Avdelning/ar
Publiceringsår
2008
Språk
Engelska
Sidor
3997-4002
Publikation/Tidskrift/Serie
Anticancer research
Volym
28
Issue
6B
Dokumenttyp
Artikel i tidskrift
Förlag
International Institute of Cancer Research
Ämne
- Cancer and Oncology
Nyckelord
- immunotherapy
- Non-small cell lung cancer
- cytokine-induced killer cells
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1791-7530