Ultrasome: efficient aberration caller for copy number studies of ultra-high resolution

Summary, in English

Motivation: Multimillion-probe microarrays allow detection of gains and losses of chromosomal material at unprecedented resolution. However, the data generated by these arrays are several-fold larger than data from earlier platforms, creating a need for efficient analysis tools that scale robustly with data size. Results: We developed a new aberration caller, Ultrasome, that delineates genomic changes-of-interest with dramatically improved efficiency. Ultrasome shows near-linear computational complexity and processes latest generation copy number arrays about 10 000 times faster than standard methods with preserved analytic accuracy.

• Författare: Björn Nilsson; Mikael Johansson; Fatima Al-Shahrour; Anne E. Carpenter; Benjamin L. Ebert
• Avdelning/ar: Avdelningen för hematologi och transfusionsmedicin
• Publiceringsår: 2009
• Språk: Engelska
• Sidor: 1078-1079
• Publikation/Tidskrift/Serie: Bioinformatics
• Volym: 25
• Issue: 8
• Länkar: http://dx.doi.org/10.1093/bioinformatics/btp091
• Dokumenttyp: Artikel i tidskrift
• Förlag: Oxford University Press
• Ämne: Bioinformatics and Systems Biology
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1367-4803