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Evidence for Cardiomyocyte Renewal in Humans

  • Olaf Bergmann
  • Ratan D. Bhardwaj
  • Samuel Bernard
  • Sofia Zdunek
  • Fanie Barnabe-Heider
  • Stuart Walsh
  • Joel Zupicich
  • Kanar Alkass
  • Bruce A. Buchholz
  • Henrik Druid
  • Stefan Jovinge
  • Jonas Frisen
Publiceringsår: 2009
Språk: Engelska
Sidor: 98-102
Publikation/Tidskrift/Serie: Science
Volym: 324
Nummer: 5923
Dokumenttyp: Artikel
Förlag: American Association for the Advancement of Science (AAAS)


It has been difficult to establish whether we are limited to the heart muscle cells we are born with or if cardiomyocytes are generated also later in life. We have taken advantage of the integration of carbon-14, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes renew, with a gradual decrease from 1% turning over annually at the age of 25 to 0.45% at the age of 75. Fewer than 50% of cardiomyocytes are exchanged during a normal life span. The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work toward the development of therapeutic strategies aimed at stimulating this process in cardiac pathologies.



  • Medicine and Health Sciences


  • ISSN: 0036-8075

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