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Complement evasion strategies of pathogens-Acquisition of inhibitors and beyond.

In English

Författare

Summary, in English

Activation of the complement system and resulting opsonisation with C3b are key events of the innate immune defense against infections. However, a wide variety of bacterial pathogens subvert complement attack by binding host complement inhibitors such as C4b-binding protein, factor H and vitronectin, which results in diminished opsonophagocytosis and killing of bacteria by lysis. Another widely used strategy is production of proteases, which can effectively degrade crucial complement components. Furthermore, bacterial pathogens such as Moraxella catarrhalis and Staphylococcus aureus capture and incapacitate the key complement component C3. The current review describes examples of these three strategies. Targeting binding sites for complement inhibitors on bacterial surfaces and complement-degrading proteases with vaccine-induced antibodies may be used to enhance a common vaccine design strategy that depends on the generation of complement-dependent bactericidal and opsonophagocytic antibody activities.

Publiceringsår

2009

Språk

Engelska

Sidor

2808-2817

Publikation/Tidskrift/Serie

Molecular Immunology

Volym

46

Dokumenttyp

Artikel i tidskrift

Förlag

Pergamon Press Ltd.

Ämne

  • Immunology in the medical area

Status

Published

Forskningsgrupp

  • Protein Chemistry, Malmö
  • Clinical Microbiology, Malmö

ISBN/ISSN/Övrigt

  • ISSN: 1872-9142