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Functional Adaptation of BabA, the H. pylori ABO Blood Group Antigen Binding Adhesin

Författare:
  • Marina Aspholm-Hurtig
  • Giedrius Dailide
  • Martina Lahmann
  • Awdhesh Kalia
  • Dag Ilver
  • Niamh Roche
  • Susanne Vikström
  • Rolf Sjöström
  • Sara Lindén
  • Anna Bäckström
  • Carina Lundberg
  • Anna Arnqvist
  • Jafar Mahdavi
  • Ulf Nilsson
  • Billie Velapatiño
  • Robert H Gilman
  • Markus Gerhard
  • Teresa Alarcon
  • Manuel López-Brea
  • Teruko Nakazawa
  • James G Fox
  • Pelayo Correa
  • Maria Gloria Dominguez-Bello
  • Guillermo I Perez-Perez
  • Martin J Blaser
  • Staffan Normark
  • Ingemar Carlstedt
  • Stefan Oscarson
  • Susann Teneberg
  • Douglas E Berg
  • Thomas Borén
Publiceringsår: 2004
Språk: Engelska
Sidor: 519-522
Publikation/Tidskrift/Serie: Science
Volym: 305
Nummer: 5683
Dokumenttyp: Artikel
Förlag: American Association for the Advancement of Science

Sammanfattning

Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens (generalists), whereas 60% of adherent South American Amerindian strains bind blood group O antigens best (specialists). This specialization coincides with the unique predominance of blood group O in these Amerindians. Strains differed about 1500-fold in binding affinities, and diversifying selection was evident in babA sequences. We propose that cycles of selection for increased and decreased bacterial adherence contribute to babA diversity and that these cycles have led to gradual replacement of generalist binding by specialist binding in blood group O–dominant human populations.

Disputation

Nyckelord

  • Chemistry
  • Biology and Life Sciences

Övriga

Published
Yes
  • ISSN: 0036-8075

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