Heparan sulphate proteoglycans: the sweet side of development.
Författare
Summary, in English
Pattern formation during development is controlled to a great extent by a small number of conserved signal transduction pathways that are activated by extracellular ligands such as Hedgehog, Wingless or Decapentaplegic. Genetic experiments have identified heparan sulphate proteoglycans (HSPGs) as important regulators of the tissue distribution of these extracellular signalling molecules. Several recent reports provide important new insights into the mechanisms by which HSPGs function during development.
Publiceringsår
2005
Språk
Engelska
Sidor
530-541
Publikation/Tidskrift/Serie
Nature Reviews. Molecular Cell Biology
Volym
6
Issue
7
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Nature Publishing Group
Ämne
- Basic Medicine
Nyckelord
- Glycosaminoglycans: biosynthesis
- Gene Expression Regulation
- Animals
- N.I.H.
- U.S. Gov't
- P.H.S.
- Signal Transduction
- Non-U.S. Gov't
- Research Support
- Extramural
- Heparan Sulfate Proteoglycan: genetics
- Heparan Sulfate Proteoglycan: physiology
- Humans
- Mutation
Status
Published
Forskningsgrupp
- Invertebrate Developmental Biology, Udo Haecker's group
ISBN/ISSN/Övrigt
- ISSN: 1471-0072