From the fetal liver to spleen and gut: the highway to natural antibody
Författare
Summary, in English
The film of sIgA lining the intestinal epithelium plays a role in the regulation of the commensal microflora and prevention of pathogen invasion. We show that, in the absence of intentional immunization, all sIgA in the gut is produced by B-1a B cells. We also show that B-1a B cells and sIgA derive from lineage-negative precursors found in the fetal liver and located in the spleen after birth. The splenic precursors do not generate B cells of the adaptive immune system in bone marrow, spleen, and lymph nodes, but efficiently replenish the cells producing the natural antibodies. Therefore, B-1a B cells with their splenic progenitors and their progeny of plasma cells fill the same function of the primordial immune system of lower vertebrates. The natural antibodies in the serum and on the intestinal epithelium may be an evolutionary ancient tool for the immediate protection against commensal and pathogenic bacteria.
Avdelning/ar
- Immunology
Publiceringsår
2009
Språk
Engelska
Sidor
351-361
Publikation/Tidskrift/Serie
Mucosal Immunology
Volym
2
Issue
4
Dokumenttyp
Artikel i tidskrift
Förlag
Nature Publishing Group
Ämne
- Immunology in the medical area
Status
Published
Forskningsgrupp
- Immunology
ISBN/ISSN/Övrigt
- ISSN: 1933-0219