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Binding studies on substrate- and enantio-selective molecularly imprinted polymers

In English

Författare

Summary, in English

A molecularly imprinted polymer was prepared using tert-butyloxycarbonyl-L-phenylalanine as the print molecule and methacrylic acid as the functional monomer. The bulk polymer obtained was ground, sieved, packed into a column and investigated in the HPLC-mode by frontal chromatography to determine the number of binding sites and dissociation constants for the enantiomers interacting with the polymer. The dissociation constant for the L-enantiomer of the print molecule was lower than for the D-enantiomer (6.3 mM and 8.1 mM, respectively). This means that the affinity for the L-enantiomer was higher than for the D-enantiomer. The number of binding sites in the polymer giving rise to these dissociation constants were determined to be 28 μmol per g dry polymer.

Publiceringsår

1991

Språk

Engelska

Sidor

1137-1145

Publikation/Tidskrift/Serie

Analytical Letters

Volym

24

Issue

7

Dokumenttyp

Artikel i tidskrift

Förlag

Taylor & Francis

Ämne

  • Biochemistry and Molecular Biology

Status

Published

Forskningsgrupp

  • Nanomedicine and Biomaterials

ISBN/ISSN/Övrigt

  • ISSN: 0003-2719