Protein E of Haemophilus influenzae Is a Ubiquitous Highly Conserved Adhesin.

Summary, in English

Protein E (PE) of nontypeable Haemophilus influenzae (NTHi) is involved in adhesion and activation of epithelial cells. A total of 186 clinical NTHi isolates, encapsulated H. influenzae, and culture collection strains were analyzed. PE was highly conserved in both NTHi and encapsulated H. influenzae (96.9%-100% identity without the signal peptide). PE also existed in other members of the genus Pasteurellaceae. The epithelial cell binding region (amino acids 84-108) was completely conserved. Phylogenetic analysis of the pe sequence separated Haemophilus species into 2 separate clusters. Importantly, PE was expressed in 98.4% of all NTHi (126 isolates) independently of the growth phase.

• Författare: Birendra Singh; Marta Brant; Mogens Kilian; Björn Hallström; Kristian Riesbeck
• Avdelning/ar: Klinisk mikrobiologi, Malmö; Biologiska institutionen
• Publiceringsår: 2010
• Språk: Engelska
• Sidor: 414-419
• Publikation/Tidskrift/Serie: Journal of Infectious Diseases
• Volym: 201
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/20028233?dopt=Abstract; http://dx.doi.org/10.1086/649782
• Dokumenttyp: Artikel i tidskrift
• Förlag: Oxford University Press
• Ämne: Infectious Medicine
• Status: Published
• Forskningsgrupp: Clinical Microbiology, Malmö
• ISBN/ISSN/Övrigt: ISSN: 1537-6613