Open chromatin and diabetes risk.

Summary, in English

A new study has identified a large number of open chromatin regions harboring active regulatory elements in human pancreatic islets. A type 2 diabetes-associated SNP in TCF7L2 was found to be located in a region of allele-specific open chromatin and shows allele-specific enhancer activity, suggesting a potential mechanism for this disease association.

• Författare: Leif Groop
• Avdelning/ar: Translationell Muskel Forskning; EXODIAB: Excellence of Diabetes Research in Sweden
• Publiceringsår: 2010
• Språk: Engelska
• Sidor: 190-192
• Publikation/Tidskrift/Serie: Nature Genetics
• Volym: 42
• Issue: 3
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/20179731?dopt=Abstract; http://dx.doi.org/10.1038/ng0310-190
• Dokumenttyp: Artikel i tidskrift
• Förlag: Nature Publishing Group
• Ämne: Endocrinology and Diabetes
• Status: Published
• Forskningsgrupp: Genomics, Diabetes and Endocrinology
• ISBN/ISSN/Övrigt: ISSN: 1546-1718