Extended-spectrum beta-lactamase-producing Escherichia coli in patients with travellers' diarrhoea.
Författare
Summary, in English
Abstract The identification of patients carrying extended-spectrum beta-lactamase (ESBL)-producing bacteria is important, since these patients are at risk of receiving inappropriate empirical therapy if they become infected. The purpose of this study was to investigate the occurrence of ESBL-producing bacteria in patients with travellers' diarrhoea. Patients with travellers' diarrhoea (N = 242) having delivered stool samples for the diagnosis of Salmonella, Shigella, Yersinia or Campylobacter, were also examined for ESBL-producing Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis. The overall prevalence of faecal carriage of ESBL-producing bacteria was 24% (58/242). Of the patients who had travelled in Europe, 3% (2/63) were found to be ESBL carriers in comparison to 36% (50/138) of those who had travelled outside Europe. ESBL-producing E. coli was especially common among patients returning from India (11/14), Egypt (19/38; 50%) and Thailand (8/38; 22%). In total, 90% of the genes of the ESBL-positive samples were of CTX-M type. The CTX-M-1 group dominated, followed by the CTX-M-9 group. The repetitive sequence-based PCR fingerprint pattern showed that there was no similarity between the ESBL strains found. Patients who have travelled outside Europe are at high risk of being colonized with ESBL-producing Enterobacteriaceae, and, if infected, are also at risk of receiving inappropriate empirical antibiotic therapy.
Avdelning/ar
- Infectious Diseases Research Unit
- Klinisk mikrobiologi, Malmö
Publiceringsår
2010
Språk
Engelska
Sidor
275-280
Publikation/Tidskrift/Serie
Scandinavian Journal of Infectious Diseases
Volym
42
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Informa Healthcare
Ämne
- Infectious Medicine
Aktiv
Published
Forskningsgrupp
- Infectious Diseases Research Unit
- Clinical Microbiology, Malmö
ISBN/ISSN/Övrigt
- ISSN: 1651-1980