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Plasma concentrations of Gas6 and soluble Axl correlate with disease and predict mortality in patients with critical limb ischemia.

In English

Författare

Summary, in English

INTRODUCTION: Critical limb ischemia (CLI) is a severe peripheral arterial disease, characterized by rest pain, ulcers and gangrene in the legs. Gas6 is a vitamin K-dependent protein, which binds and activates the tyrosine kinase receptor Axl. Gas6-mediated Axl-signaling influences endothelial activation, neointima formation and immune regulation. Axl can be cleaved and soluble Axl (sAxl) is detectable in circulation. DESIGN AND METHODS: We quantified plasma concentrations of Gas6 and sAxl in 189 CLI patients and 204 controls. RESULTS: Gas6 and sAxl concentrations were increased in the CLI patients (p<0.0001) and correlated to C-reactive protein, interleukin-6, tumor necrosis factor alpha and neopterin. Patients who died within three years of sampling (n=84) had increased concentrations of Gas6 and sAxl as compared to survivors (p=0.0009 and p=0.0011). CONCLUSIONS: Plasma concentrations of Gas6 and sAxl correlate to inflammation and predict survival. This indicates that Gas6 and sAxl have a role in CLI, presumably connected to the inflammatory process.

Publiceringsår

2010

Språk

Engelska

Sidor

873-876

Publikation/Tidskrift/Serie

Clinical Biochemistry

Volym

May 4

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Biochemistry and Molecular Biology

Status

Published

Forskningsgrupp

  • Clinical Chemistry, Malmö
  • Vascular Diseases - Clinical Research

ISBN/ISSN/Övrigt

  • ISSN: 1873-2933