Feasibility of in vivo N-15 MRS detection of hyperpolarized N-15 labeled choline in rats
Författare
Summary, in English
The increase of total choline in tumors has become an important biomarker in cancer diagnosis. Choline and choline metabolites can be measured in vivo and in vitro using multinuclear MRS. Recent in vivo C-13 MRS studies using labeled substrates enhanced via dynamic nuclear polarization demonstrated the tremendous potential of hyperpolarization for real-time metabolic studies. The present study demonstrates the feasibility of detecting hyperpolarized N-15 labeled choline in vivo in a rat head at 9.4 T. We furthermore report the in vitro (172 +/- 16 s) and in vivo (126 +/- 15 s) longitudinal relaxation times. We conclude that with appropriate infusion protocols it is feasible to detect hyperpolarized N-15 labeled choline in live animals.
Avdelning/ar
Publiceringsår
2010
Språk
Engelska
Sidor
5818-5823
Publikation/Tidskrift/Serie
Physical Chemistry Chemical Physics
Volym
12
Issue
22
Dokumenttyp
Artikel i tidskrift
Förlag
Royal Society of Chemistry
Ämne
- Neurosciences
Status
Published
Forskningsgrupp
- Brain Repair and Imaging in Neural Systems (BRAINS)
ISBN/ISSN/Övrigt
- ISSN: 1463-9084