Antioxidant Effects of Secondary Metabolites from Geranium psilostemon

Summary, in English

An investigation was made of the effects on endogenous antioxidant enzyme activities and H2O2-induced lipid peroxidation inhibition in human red blood cells of the crude MeOH extract and its EtOAc, n-BuOH, and H2O sub-extracts obtained from aerial parts of Geranium psilostemon Ledeb., as well as compounds isolated from the most active EtOAc extract. Gallic acid (1), methyl gallate (2), pusilagin (3), 1,3,6-tri-O-galloyl-beta-glucopyranoside (4), 1,2,3,4,6-penta-O-galloyl-beta-glucopyranoside (5), kaempferol (6), quercetin (7), kaempferol 7-O-alpha-rhamnopyranoside (8), and quercetin 7-O-alpha-rhamnopyranoside (9) were isolated from the aerial parts of the title plant, and their structures identified from spectroscopic (UV, 1D- and 2D- NMR) and spectrometric (TOF-MS) data. All extracts and isolated compounds inhibited H2O2-induced lipid peroxidation and also enhanced the activity of superoxide dismutase (SOD) and catalase (CAT).

• Författare: Didem Sohretoglu; Suna Atasayar Sabuncuoglu; M. Koray Sakar; Hilal Ozgunes; Olov Sterner
• Avdelning/ar: Centrum för analys och syntes
• Publiceringsår: 2010
• Språk: Engelska
• Sidor: 899-902
• Publikation/Tidskrift/Serie: Natural Product Communications
• Volym: 5
• Issue: 6
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/20614819
• Dokumenttyp: Artikel i tidskrift
• Förlag: Natural Products Inc
• Ämne: Organic Chemistry
• Nyckelord: pentagalloyl glucose; trigalloyl glucose; SOD; CAT; antioxidant; Geranium; Geraniaceae
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1934-578X