High-fat diet impairs hippocampal neurogenesis in male rats.
Författare
Summary, in English
High fat diets and obesity pose serious health problems, such as type II diabetes and cardiovascular disease. Impaired cognitive function is also associated with high fat intake. In this study, we show that just 4 weeks of feeding a diet rich in fat ad libitum decreased hippocampal neurogenesis in male, but not female, rats. There was no obesity, but male rats fed a diet rich in fat exhibited elevated serum corticosterone levels compared with those fed standard rat chow. These data indicate that high dietary fat intake can disrupt hippocampal neurogenesis, probably through an increase in serum corticosterone levels, and that males are more susceptible than females.
Avdelning/ar
- Neuroendokrin cellbiologi
- Wallenberg Neuroscience Centre, Lund
- Institutionen för experimentell medicinsk vetenskap
- Aptitkontroll
Publiceringsår
2006
Språk
Engelska
Sidor
1385-1388
Publikation/Tidskrift/Serie
European Journal of Neurology
Volym
13
Issue
12
Fulltext
- Available as PDF - 81 kB
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Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Wiley-Blackwell
Ämne
- Neurology
Nyckelord
- fat intake
- obesity
- memory
- hippocampus
- corticosterone
Status
Published
Forskningsgrupp
- Neuroendocrine Cell Biology
- Appetite Regulation
ISBN/ISSN/Övrigt
- ISSN: 1351-5101