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Crossed over repair of the femoral sensory and motor branches influences N-CAM

Publiceringsår: 2010
Språk: Engelska
Sidor: 841-845
Publikation/Tidskrift/Serie: Neuroreport
Volym: 21
Nummer: 12
Dokumenttyp: Artikel
Förlag: Lippincott Williams & Wilkins


N-CAM, expressed by non-myelinating Schwann cells, was investigated by immunohistochemistry in transected rat femoral nerves, which were repaired either using a straight or a crossed over technique. N-CAM staining covered 30 and 11% of the cross-sectional area of and motor branches, respectively, in uninjured nerves. After 3 days there was a transient smaller area of N-CAM staining following both the repairs. After a straight repair N-CAM area increased to the control values in both branches. In contrast, a crossed over repair resulted in a continuous increase of N-CAM in the motor branch, whereas the area in the sensory branch returned slowly to control values. N-CAM is influenced by an intentionally misdirected outgrowth of motor and sensory axons after nerve repair. NeuroReport 21:841-845 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.



  • Medicine and Health Sciences
  • neurofilaments
  • nerve repair
  • nerve regeneration
  • N-CAM
  • axons
  • misdirection
  • non-myelinating
  • Schwann cells


  • ISSN: 0959-4965

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