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Verification that common variation at 2q37.1, 6p25.3, 11q24.1, 15q23, and 19q13.32 influences chronic lymphocytic leukaemia risk

Författare:
  • Dalemari Crowther-Swanepoel
  • Mahmoud Mansouri
  • Anna Enjuanes
  • Ana Vega
  • Karin E. Smedby
  • Clara Ruiz-Ponte
  • Jesper Jurlander
  • Gunnar Juliusson
  • Emilio Montserrat
  • Daniel Catovsky
  • Elias Campo
  • Angel Carracedo
  • Richard Rosenquist
  • Richard S. Houlston
Publiceringsår: 2010
Språk: Engelska
Sidor: 473-479
Publikation/Tidskrift/Serie: British Journal of Haematology
Volym: 150
Nummer: 4
Dokumenttyp: Artikel
Förlag: Wiley-Blackwell Publishing, Inc

Sammanfattning

P>A recent genome wide association study of chronic lymphocytic leukaemia (CLL) provided evidence that common variation at 2q13 (rs17483466), 2q37.1 (rs13397985), 6p25.3 (rs872071), 11q24.1 (rs735665), 15q23 (rs7176508) and 19q13.32 (rs11083846) affects CLL risk. To verify and further explore the relationship between these variants and CLL risk we genotyped case-control datasets from Spain and Sweden (824 cases, 850 controls). Combined data provided statistically significant support for an association between genotypes at rs13397985, rs872071, rs735665, rs7176508 and rs11083846 and CLL risk. CLL risk increased with increasing numbers of risk alleles (P-trend = 1 center dot 40 x 10-15), consistent with a polygenic model of disease susceptibility. These data validate the relationship between common variation and risk of CLL.

Disputation

Nyckelord

  • Medicine and Health Sciences
  • chronic lymphocytic leukaemia
  • risk
  • genotype
  • genome wide association

Övriga

Published
Yes
  • ISSN: 0007-1048

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