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On the adaptive significance of stress-induced immunosuppression

Publiceringsår: 1998
Språk: Engelska
Sidor: 1637-1641
Publikation/Tidskrift/Serie: Proceedings of the Royal Society of London Series B-Biological Sciences
Volym: 265
Nummer: 1406
Dokumenttyp: Artikel
Förlag: Royal Society Publishing

Sammanfattning

We approach the field of stress immunology from an ecological point of view and ask: why should a heavy physical workload, for example as a result of a high reproductive effort, compromise immune function? We argue that immunosuppression by neuroendocrine mechanisms, such as stress hormones, during heavy physical workload is adaptive, and consider two different ultimate explanations of such immunosuppression. First, several authors have suggested that the immune system is suppressed to reallocate resources to other metabolic demands. In our view, this hypothesis assumes that considerable amounts of energy or nutrients can be saved by suppressing the immune system; however, this assumption requires further investigation. Second, we suggest an alternative explanation based on the idea that the immune system is tightly regulated by neuroendocrine mechanisms to avoid hyperactivation and ensuing autoimmune responses. We hypothesize that the risk of autoimmune responses increases during heavy physical workload and that the immune system is suppressed to counteract this.

Disputation

Nyckelord

  • Biology and Life Sciences
  • immune-system
  • strenuous exercise
  • reproductive effort
  • pituitary-adrenal axis
  • exercise
  • strenuous
  • sexual selection
  • cost of reproduction
  • immunocompetence
  • autoimmunity
  • proteins
  • cost
  • recognition
  • hypotheses
  • endocrine

Övriga

Published
  • Costs of the immune system and maternal effects
Yes
  • Molecular Ecology and Evolution Lab
  • ISSN: 0962-8452

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