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Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors

Författare

  • M Thullberg
  • J Bartkova
  • S Khan
  • Klaus Hansen
  • Lars Rönnstrand
  • Jiri Lukas
  • M Strauss
  • Jiri Bartek

Summary, in English

p16(INK4a), p15(INK4b), p18(INK4c) and p19(INK4d) comprise a family of cyclin-dependent kinase inhibitors and tumor suppressors. We report that the INK4 proteins share the ability to arrest cells in G1, and interact with CDK4 or CDK6 with similar avidity. In contrast, only p18 and particularly p19 are phosphorylated in vivo, and each of the human INK4 proteins shows unique expression patterns dependent on cell and tissue type, and differentiation stage. Thus, the INK4 proteins harbor redundant as well as non-overlapping properties, suggesting distinct regulatory modes, and diverse roles for the individual INK4 family members in cell cycle control, cellular differentiation, and multistep oncogenesis.

Publiceringsår

2000

Språk

Engelska

Sidor

161-166

Publikation/Tidskrift/Serie

FEBS Letters

Volym

470

Issue

2

Dokumenttyp

Artikel i tidskrift

Förlag

Wiley-Blackwell

Ämne

  • Medicinal Chemistry

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1873-3468