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Differential expression of anti-Müllerian hormone (amh) and anti-Müllerian hormone receptor type II (amhrII) in the teleost medaka

Författare:
  • Nils Klüver
  • Frank Pfennig
  • Irene Pala
  • Katja Storch
  • Marlen Schlieder
  • Alexander Froschauer
  • Herwig O. Gutzeit
  • Manfred Schartl
Publiceringsår: 2007
Språk: Engelska
Sidor: 271-281
Publikation/Tidskrift/Serie: Developmental Dynamics
Volym: 236
Nummer: 1
Dokumenttyp: Artikel
Förlag: John Wiley & Sons, Inc.

Sammanfattning

Abstract 10.1002/dvdy.20997.abs In mammals, the anti-Müllerian hormone (Amh) is responsible for the regression of the Müllerian ducts; therefore, Amh is an important factor of male sex differentiation. The amh gene has been cloned in various vertebrates, as well as in several teleost species. To date, all described species show a sexually dimorphic expression of amh during sex differentiation or at least in differentiated juvenile gonads. We have identified the medaka amh ortholog and examined its expression pattern. Medaka amh shows no sexually dimorphic expression pattern. It is expressed in both developing XY male and XX female gonads. In adult testes, amh is expressed in the Sertoli cells and in adult ovaries in granulosa cells surrounding the oocytes, like in mammals. To better understand the function of amh, we cloned the anti-Müllerian hormone receptor type II (amhrII) ortholog and compared its expression pattern with amh, aromatase (cyp19a1), and scp3. During gonad development, amhrII is coexpressed with medaka amh in somatic cells of the gonads and shows no sexually dimorphic expression. Only the expression level of the Amh type II receptor gene was decreased noticeably in adult female gonads. These results suggest that medaka Amh and AmhrII are involved in gonad formation and maintenance in both sexes. Developmental Dynamics 236:271–281, 2007. © 2006 Wiley-Liss, Inc.

Disputation

Nyckelord

  • Biology and Life Sciences
  • medaka
  • MIS
  • gonad development
  • AmhrII
  • Amh type II receptor
  • anti-Müllerian hormone
  • Amh
  • sex determination
  • sex differentiation

Övriga

Published
Yes
  • ISSN: 1097-0177

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