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TP53 Mutations are infrequent in newly diagnosed chronic lymphocytic leukemia

Författare:
Publiceringsår: 2011
Språk: Engelska
Sidor: 272-274
Publikation/Tidskrift/Serie: Leukemia Research
Volym: 35
Nummer: 2
Dokumenttyp: Artikel
Förlag: Pergamon-Elsevier Science Ltd

Sammanfattning

TP53 mutations in the absence of 17p-deletion correlate with rapid disease progression and poor survival in chronic lymphocytic leukemia (CLL). Herein, we determined the TP53 mutation frequency in 268 newly diagnosed CLL patients from a population-based material. Overall, we detected TP53 mutations in 3.7% of patients (n = 10), where 7/10 cases showed a concomitant 17p-deletion, confirming the high prevalence of TP53 mutation in 17p-deleted patients. Only 3 (1.1%) of the newly diagnosed patients in our cohort thereby carried TP53 mutations without 17p-deletion, a frequency that is much lower than previous reports on referral cohorts (3-6%). Our findings imply that TP53 mutations are rare at CLL onset and instead may arise during disease progression. (C) 2010 Elsevier Ltd. All rights reserved.

Disputation

Nyckelord

  • Medicine and Health Sciences
  • TP53 mutation
  • 17p-deletion
  • Prognosis
  • Chronic lymphocytic leukemia

Övriga

Published
Yes
  • ISSN: 0145-2126

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