Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient
Författare
Summary, in English
Synaptic dopamine release from embryonic nigral transplants has been monitored in the striatum of a patient with Parkinson's disease using [11C]-raclopride positron emission tomography to measure dopamine D2 receptor occupancy by the endogenous transmitter. In this patient, who had received a transplant in the right putamen 10 years earlier, grafts had restored both basal and drug-induced dopamine release to normal levels. This was associated with sustained, marked clinical benefit and normalized levels of dopamine storage in the grafted putamen. Despite an ongoing disease process, grafted neurons can thus continue for a decade to store and release dopamine and give rise to substantial symptomatic relief.
Avdelning/ar
- Neurobiologi
- Institutionen för experimentell medicinsk vetenskap
- Older people's health and Person-Centred care
- Neurokirurgi
- Neurologi, Lund
Publiceringsår
1999
Språk
Engelska
Sidor
1137-1140
Publikation/Tidskrift/Serie
Nature Neuroscience
Volym
2
Issue
12
Dokumenttyp
Artikel i tidskrift
Förlag
Nature Publishing Group
Ämne
- Neurosciences
Status
Published
Forskningsgrupp
- Neurobiology
- Older people's health and Person-Centred care
ISBN/ISSN/Övrigt
- ISSN: 1546-1726