A novel gene family encoding proteins with highly differing structure because of a rapidly evolving exon
Författare
Summary, in English
Despite vast differences in primary structure, it is here shown that several predominant semen proteins are encoded by genes that belongs to a common family. Members have their transcription unit split into three exons: the first encoding the signal peptide, the second the secreted protein, while the third exon solely consists of 3' non-translated nucleotides. The first and the third exon are conserved between members, but the second exon is not. The genes for human semenogelins I and II, rat SVSII, SVSIV, SVSV and guinea pig GP1 and GP2 belong to this gene family.
Avdelning/ar
Publiceringsår
1995
Språk
Engelska
Sidor
6-53
Publikation/Tidskrift/Serie
FEBS Letters
Volym
374
Issue
1
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Wiley-Blackwell
Ämne
- Medicinal Chemistry
Nyckelord
- *Prostatic Secretory Proteins
- *Multigene Family
- Molecular Sequence Data
- Male
- Humans
- Guinea Pigs
- Gonadal Steroid Hormones/genetics
- *Exons
- Molecular
- *Evolution
- Dna
- Conserved Sequence
- Animals
- Base Sequence
- Proteins/*genetics
- Rats
- Research Support
- Non-U.S. Gov't
- *Semen
- Seminal Plasma Proteins
- Seminal Vesicle Secretory Proteins
- Sequence Homology
- Nucleic Acid
Status
Published
Forskningsgrupp
- Clinical Chemistry, Malmö
ISBN/ISSN/Övrigt
- ISSN: 1873-3468